I run an asus p5e-hdmi micro-atx board in it. It isnt one of the latest micro atx media boards because i have had it hanging around at the house for nearly a year now. I then push the audio out via coaxial to a sony av receiver running a 5.1 tanoy speakers.
The only problem I had with it was that the remote and variable control on the front of the case didnt adjust the sound / audio. Having researched the Antec support area, they suggested upgrading the latest driver software for the vfd (lcd panel) and your motherboard. Both of which still didnt make it work.
Then I saw that on the Asus support site that there was a realtek driver for the audio. I then replaced the microsoft standard driver for the audio with the Realtek one and bazaaam it all works.
The only outstanding problem I have is that Microsoft Media Center doesnt control the audio when playing a dvd, but I have had this problem on my older media center so think Media Center cant control it as the ouput just seems to off load it out the coaxial audio cable to my av receiver.
The results are outstanding just need to upgrade my lcd tv to a full HD (1080p) one now rather than a HD-Ready (720p) but that will have to wait.
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